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KMID : 0861120150190020123
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Korean Journal of Oriental Preventive Medicine
2015 Volume.19 No. 2 p.123 ~ p.133
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Safety classification for frequently-used herbal medicines inducing toxic metabolites
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Park Yeong-Chul
Lee Sun-Dong
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Abstract
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The new formular for herbal medicine-safety classification in terms of evidence-based medicine was developed and applied to evaluate various herbal medicines in the previous study. This study is aimed to evaluate the frequently-used herbal medicines inducing toxic metabolites or reactive intermediates(RI), such as Ligusticum wallichii Franch, Angelica sinensis, Glycyrrhizae Radix, Rehmanniae Radix, based on 6 safety grades calculated from human equivalent dose(HED)-based MOS(margin of safety). HED-based MOS can be explained as the ratio of theoretical ALD(approximate lethal dose) of human as LD1(lethal dose of 1%)/ clinical maximum dose as ED99(Effective dose of 99%). The herbal medicine showing the ratio less than 1 belongs to Class 1, but the herbal medicine showing the ratio more than 500 belongs to Class 6 with the lowest toxicity. As a result, they were evaluated as class 2 for Angelica sinensis and Glycyrrhizae Radix, class 3 for Ligusticum wallichii Franch and Rehmanniae Radix. These resultant grades for 4 herbal medicines were lower than the grade expected under consideration that these herbal medicines are used very frequently in oriental clinics. These low grades would be due to their ingredients which is biotransformed to toxic metabolites.
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KEYWORD
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Herbal medicine, Safety classification, HED-based MOS, Toxic metabolites, Reactive intermediates
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